DNA Alzheimer’s Disease Risk Test
$195.00
Discover whether you are at risk of developing late-onset Alzheimer’s disease, especially if it runs in your family.
This DNA test can detect the presence of the APOE e4 variant, which has a strong association with the disease. Those with this variant are at a 3 to 15 times higher risk of developing the condition. If you are concerned about your risk of Alzheimer’s, this test can provide valuable information to help you take the necessary steps to manage your health.
- Collection method: Buccal swabs
- Private and confidential online results
Description
Alzheimer’s disease is a degenerative neurological disorder that gradually impairs memory and other cognitive functions. Late-onset Alzheimer’s disease accounts for over 90% of cases, with symptoms typically emerging after the age of 65.
The brains of individuals with Alzheimer’s disease exhibit two distinct abnormalities: plaques and tangles. Plaques, composed of a protein called beta-amyloid, disrupt communication between nerve cells. Tangles occur when tau proteins, which normally form parallel strings within nerve cells, disintegrate into a twisted mass. This collapse of tau tracks hinders the transport of vital nutrients and resources.
The accumulation of plaques and tangles leads to the destruction of cells, as observed in Alzheimer’s disease. By taking this test, you can determine whether you are at risk of developing this condition and make positive lifestyle changes to promote brain health.
Description
Alzheimer’s disease is a degenerative neurological disorder that gradually impairs memory and other cognitive functions. Late-onset Alzheimer’s disease accounts for over 90% of cases, with symptoms typically emerging after the age of 65.
The brains of individuals with Alzheimer’s disease exhibit two distinct abnormalities: plaques and tangles. Plaques, composed of a protein called beta-amyloid, disrupt communication between nerve cells. Tangles occur when tau proteins, which normally form parallel strings within nerve cells, disintegrate into a twisted mass. This collapse of tau tracks hinders the transport of vital nutrients and resources.
The accumulation of plaques and tangles leads to the destruction of cells, as observed in Alzheimer’s disease. By taking this test, you can determine whether you are at risk of developing this condition and make positive lifestyle changes to promote brain health.
Our testing laboratory is AABB Accredited, ISO/IEC 17025 Certified and participates in the CAP proficiency testing program.
Technical Info
The risk of developing late-onset Alzheimer’s disease is largely influenced by genetic factors, with the APOE gene being the strongest predictor. The APOE gene is responsible for producing apolipoprotein E, which plays a vital role in transporting fats, promoting neuronal growth, aiding in nerve regeneration, regulating the immune system, and repairing injuries in the central nervous system.
There are 3 common variations, or alleles, of the APOE gene: e2, e3, and e4. Each individual inherits two copies of the gene, and their genotype determines their risk of developing late-onset Alzheimer’s disease:
- e2/e2 – reduced risk
- e2/e3 – reduced risk
- e2/e4 – 3X increased risk
- e3/e3 – does not affect your risk
- e3/e4 – 3X increased risk
- e4/e4 – 10X to 15X increased risk
Knowing your APOE genotype can encourage early monitoring and prompt treatment to delay the onset or progression of Alzheimer’s disease.
