DNA Celiac Disease Test
$249.00
The vast majority of individuals with celiac disease carry at least one genetic risk allele. A DNA test can help determine your risk for developing celiac disease by analyzing specific genetic markers associated with the condition.
- Analyzes HLA gene variants associated with higher risk for the condition.
- Accurate even on a gluten-free diet
- No age limit
- Collection method: Buccal swabs
- Private and confidential online results
Description
Celiac disease is an autoimmune disorder that results in the immune system mistakenly attacking healthy cells. People with celiac disease are highly sensitive to gluten, a protein found in wheat, rye, barley, and oats. When someone with celiac disease consumes gluten, their immune system reacts abnormally, causing significant damage to the lining of the small intestine and leading to a variety of health complications. Genetic analysis is available to determine whether someone has a genetic predisposition to celiac disease, but it does not require the consumption of gluten. The testing process involves a simple DNA sample taken from a mouth swab.
Description
Celiac disease is an autoimmune disorder that results in the immune system mistakenly attacking healthy cells. People with celiac disease are highly sensitive to gluten, a protein found in wheat, rye, barley, and oats. When someone with celiac disease consumes gluten, their immune system reacts abnormally, causing significant damage to the lining of the small intestine and leading to a variety of health complications. Genetic analysis is available to determine whether someone has a genetic predisposition to celiac disease, but it does not require the consumption of gluten. The testing process involves a simple DNA sample taken from a mouth swab.
Our testing laboratory is AABB Accredited, ISO/IEC 17025 Certified and participates in the CAP proficiency testing program.
Technical Info
The majority of people with celiac disease have at least one genetic risk allele in their HLA genes. Specifically, a DNA test can detect changes in the three CD-associated alleles of the HLA-DQA1 and HLA-DQB1 genes (HLA-DQA105, HLA-DQB102, HLA-DQB1*0302). These alleles can pair together to form proteins called DQ2 and DQ8, which are strongly associated with an increased risk of developing gluten sensitivity and celiac disease.
Conversely, if none of these CD-associated alleles are present, the risk of developing celiac disease is extremely low. It’s worth noting that while the presence of these genetic variants can indicate an increased risk, they are not the sole determinant of whether someone will develop the condition. Other factors, such as environmental triggers, also play a role in the development of celiac disease.
